| Gene name: | CTSK |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF,NHDF |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis//BrdU assay |
| Description: | NHDF lacking cathepsin X exhibited a flattened cell body and a significant increase in size in comparison to control cells expressing normal amounts of cathepsin X. Quantification of SA-β-gal in NHDF lacking cathepsin X clearly demonstrated a significant increase both in the number of stained cells and in the intensity of staining .Cathepsin X-deficient MEF displayed a reduced cell growth when assayed by two different cell proliferation assays employing different DNA labeling techniques. The number of BrdU(+) cells which had gone through cell division (2 N DNA content) was significantly lower 24h after the pulse in cells lacking cathepsin X indicating a delayed G1 entry. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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