| Gene name: | RPS6KB1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | S6K1 increases the number of positively stained SA-β-gal cells, elevates p53-S15 and p21Cip1 levels, and enhances VCAM1 and ICAM1 expression, demonstrating that persistent hyperActivate S6K1 promotes endothelial senescence and inflammation. |
| Target gene: | ARG-II |
| Official symbol(s): | ARG-II |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR |
| Target gene description: | Indeed, in young endothelial cells, overexpression of a constitutively Activate S6K1 mutant (HA-S6K1ca), but not the inActivate S6K1 mutant, which is confirmed by immunoblotting with the anti-S6K1 antibody that detects both mutants, enhances Arg-II mRNA and protein levels paralleled with increased arginase activity. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...