| Gene name: | CCN1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Skin |
| Cell name: | -- |
| Experiment: | Atomic force microscopy imaging |
| Description: | This increase of CCN1 was associated with constitutively reduced type I collagen, and constitutively elevated MMP-1 in forearm chronically sun-exposed prematurely aged human skin. |
| Target gene: | IL-1β |
| Official symbol(s): | IL1B |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR//ELISA |
| Target gene description: | Elevated expression of CCN1 in dermal fibroblasts resulted in significant upregulation of IL-1βmRNA and protein levels.Importantly, knockdown of CCN1 induction significantly reduced UV irradiation induction of IL-1β mRNA and protein levels, indicating that induction of IL-1β is dependent, in part, on induction of CCN1. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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