| Gene name: | SIRT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Lung |
| Cell name: | Clara |
| Gene ID: | 23411 |
| Category: | protein coding |
| Phenotype: | Chronic obstructive pulmonary disease |
| Experimental category: | L |
| PMID: | 22546858 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | We found that the level of SIRT1 was decreased, whereas senescence-associated β-gal activ-ity and p21 expression were increased in lungs of COPD patients compared with nonsmokers.CS exposure significantly increased the levels of prosenescent proteins (i.e., p21, p16, and p53) and SA–β-gal activity in lungs of Sirt1+/– mice versus WT littermates, whereas these levels were lowered by Sirt1 overexpression. |
| Target gene: | FOXO3//P21 |
| Official symbol(s): | FOXO3//P21 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | SA-β-gal activity assay//Western blot |
| Target gene description: | Foxo3–/– mice exhibited heightened levels of p21, p16, p27, and SA–β-gal activity in lungs in response to CS exposure.However, there was no significant change in SA–β-gal activity in lungs of p21–/– mice in response to CS exposure, or along with sirtinol treatment.Moreover, FOXO3 acetylation was increased in Sirt1+/– mice,but lowered in Sirt1 Tg mice exposed to CS for 6 months. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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