| Gene name: | SIRT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | ECFC |
| Experiment: | Western blot//SA-β-gal activity assay//BrdU assay//Cell morphological analysis |
| Description: | Twenty-four hours after transient transfection, SIRT1 overexpression was associated with a significant decrease in the level of the senescence-associated p16INK4a protein;Consistently,transfection of PT-ECFCs with the SIRT1 vector significantly reduced SA-β-gal activity and senescence associated morphological changes, compared with PT-ECFCs transfected with an empty vector;SIRT1 overexpression accelerated PT-ECFC proliferation. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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