| Gene name: | RHEB |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Bone |
| Cell name: | Articular Chondrocyte |
| Gene ID: | 6009 |
| Category: | protein coding |
| Phenotype: | Osteoarthritis |
| Experimental category: | L |
| PMID: | 31229684 |
| Experiment: | SA-β-gal activity assay//DAPI staining |
| Description: | RHEB- 9 overexpression not only recovered the morphology of the DCs, but also reduced senescence by 10 35–40 %. RHEB-overexpression also decreased ROS levels. |
| Target gene: | COL2A1//SOX9 |
| Official symbol(s): | COL2A1//SOX9 |
| R-AG-Target gene: | Upregulation//Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Importantly, 11 RHEB -overexpression increased the level of COL2A1, which was almost negligible in non-transfected DCs. SOX9 expression also increased with RHEB -overexpressing DCs. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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