| Gene name: | EGF |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U251MG |
| Gene ID: | 1950 |
| Category: | protein coding |
| Phenotype: | Glioblastoma |
| Experimental category: | HL |
| PMID: | 30514230 |
| Experiment: | SA-β-gal activity assay |
| Description: | On the 4th day after H2O2 treatment, we observed less senescence in U251MG cells treated with EGF compared with non-EGF treated cells. On the 7th day after H2O2 treatment, the number of senescent cells in the EGF treatment group was significantly less than that in the non-treatment control group.There was a significant difference in U251MG senescence between cells treated and not treated with EGF for 7?days. With EGF (40?ng/ml) treatment, senescence of U251MG cells induced by H2O2 decreased. The concentration of 40?ng/ml EGF inhibited U251MG cell senescence efficiently. |
| Target gene: | NTN4 |
| Official symbol(s): | NTN4 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR//Immunostaining |
| Target gene description: | We observed that NTN4 expression were significantly increased upon EGF stimulation at both mRNA level and protein level. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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