| Gene name: | SIRT6 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Experiment: | BrdU assay//SA-β-gal activity assay//Immunostaining |
| Description: | SIRT6-silenced cultures showed decreased rates of proliferation and a reduction in the cell fraction passing through the S-phase.SIRT6-silenced cultures also displayed an increase in the proportion of SA-β-gal+ cells.In SIRT6-depleted HUVEC, there was a significant increase in γH2AX foci. |
| Regulatory pathway: | P21 |
| R-AG-Pathway: | -- |
| Official symbol(s): | CDKN1A |
| Pathway experiment: | Western blot |
| Pathway description: | This analysis showed higher levels of p21 expression in SIRT6-depleted cells compared with controls. |
Annotation:
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