| Gene name: | SMARCD1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | TIG-1,Hepatocyte,Hepatocyte |
| Experiment: | Knockdown//Western blot//SA-β-gal activity assay |
| Description: | Results show that the relative number of cells with increased senescence-associated βgalactosidase (SA-β-Gal) activity, p16/p21 expression, and phospho p38 (p-p38) expression is increased in SMARCD1-silenced TIG1 cells.In contrast, cellular senescence was shown to be suppressed in senescent TIG-1 cells (61 PDL) where SMARCD1 was ectopically expressed, as evidenced by a decreased number of senescence marker-positive cells in SMARCD1-overexpressing TIG-1 cells. Furthermore, SMARCD1 expression attenuated the replicative senescence-induced growth retardation.we evaluated the effect of Smarcd1-knockdown on the cellular senescence induction in mouse primary hepatocytes, indicating that Smarcd1 knockdown also induced cellular senescence in normal hepatocytes. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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