| Gene name: | JPT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | A549,HUVEC |
| Experiment: | CCK-8 assay//SA-β-gal activity assay//EdU assay//qRT-PCR//Knockdown |
| Description: | All three cell lines showed decreased proliferation rate and increased percentage of senescence-associated SA-β-Gal positive cells.Second, decreased DNA synthesis rate was observed in HN1-KD cells by the EdU incorporation assay.LMNB1, a senescence marker indicating nuclear changes of senescent cells ,showed significantly decreased expression in both HN1-KD HUVECs and A549 cells.The result showed that HN1-KD induced down-regulation of CDK1, CCNB1 and up-regulation of IL6 in both HUVECs and A549 cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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