| Gene name: | SQSTM1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | PaSC |
| Gene ID: | 8878 |
| Category: | protein coding |
| Phenotype: | Pancreatic ductal adenocarcinoma |
| Experimental category: | HL |
| PMID: | 31182922 |
| Experiment: | SA-β-gal activity assay//Knockdown//Flow cytometry//qRT-PCR |
| Description: | qPCR analysis corroborated the upregulation of these genes including IL-8, CXCL1, CXCL2, CCL2, and CCL20. This transcriptional change suggested an inflammatory and senescent phenotype of PaSCs. Flow cytometry analysis showed that FAP expression was increased in sqstm1 shRNA-transfected PaSCs. Consistently, β-galactosidase staining demonstrated that downregulation of sqstm1 in PaSCs led to enhanced senescence. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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