| Gene name: | SHH |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Human endometrial stem cell |
| Gene ID: | 6469 |
| Category: | protein coding |
| Phenotype: | Recurrent pregnancy loss |
| Experimental category: | HL |
| PMID: | 31080015 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | Importantly, SHH significantly attenuated replicative senescenceinduced SA-β-Gal activity.The oxidative stress-induced expression of these senes- cence-associated (L-6, p16,p18, and p21) was significantly attenuated by SHH treatment. We conducted the additional set of experiments to further confirm the alleviating effects of SHH on oxidative stress- induced senescence with additional aging markers, such as RB1 and P14ARF. Consistently, oxidative stress-induced expression of these senescence-associated markers was significantly attenuated by SHH treatment. |
| Target gene: | SERPINB2 |
| Official symbol(s): | SERPINB2 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//qRT-PCR |
| Target gene description: | Consistent with our hypothesis, replicative and oxidative stress-induced senescence significantly enhanced SERPINB2 expression at both the mRNA and protein levels.SHH treatment markedly suppressed SERPINB2 expression in endometrial stem cells. Importantly, senescence-induced SERPINB2 expression was significantly attenuated by SHH treatment at both the mRNA and protein levels. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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