| Gene name: | CXCL8 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUVEC |
| Experiment: | SA-β-gal activity assay//PI staining//Flow cytometry |
| Description: | However, IL-8 dose-dependently inhibited the increase of SA-beta-gal-positive cells when co-incubated with HUVECs.These results suggested that 150 μM H2O2 inhibited cell cycle progression at G1 phase, however IL-8 prevented this effect. |
| Target gene: | HTERT |
| Official symbol(s): | HTERT |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR |
| Target gene description: | QRT-PCR analysis showed that H2O2 down-regulated the expression of hTERT mRNA and the effect was suppressed by IL-8 in a dose- dependent manner. |
| Regulatory pathway: | NF-κB//P38 MAPK |
| R-AG-Pathway: | Downregulation//Downregulation |
| Official symbol(s): | NFKB1//MAKP14 |
| Pathway experiment: | Western blot |
| Pathway description: | H2O2 was found to activate NF-κB and p38(MAPK) pathway in a time-dependent manner, but the effect was suppressed by pretreatment of IL-8. |
Annotation:
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