| Gene name: | SKP2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF |
| Gene ID: | 6502 |
| Category: | protein coding |
| Phenotype: | Prostate cancer |
| Experimental category: | L |
| PMID: | 20237562 |
| Experiment: | SA-β-gal activity assay |
| Description: | We also found that the ability of Ras to induce cellular senescence was far greater in Skp2-/- MEFs than in wild-type MEFs. |
| Target gene: | P27//P21//ATF4 |
| Official symbol(s): | P27//P21//ATF4 |
| R-AG-Target gene: | --//--//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Although p53 and p19Arf levels remained unchanged, we found that Skp2 deficiency cooperated with Pten inactivation or Arf loss to induce p27 expression. p21 expression was also increased in Pten+/- Skp2-/- and Arf-/- Skp2-/- MEFs.In contrast, Atf4 was markedly induced in Pten+/- Skp2-/- MEFs. Likewise, we also observed a marked increase in Atf4 protein levels, but not p-Perk, in Arf-/- Skp2-/- MEFs. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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