| Gene name: | IL4 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | CAKI-1,A498,786-O |
| Experiment: | Flow cytometry//Cell morphological analysis//SA-β-gal activity assay//Western blot//SAHF |
| Description: | Indeed, after exposure to IL-4 for 3–7 days, the cells underwent a profound morphological change characteristic of cellular senescence such as flattening and enlargement . Flow cytometric analysis showed that Caki-1 cells exposed to IL-4 for 7 days increased in size and granularity.Up-regulation of SA-β-gal activity increased protein expression of p21WAF1/CIP1 and p16INK4A and formation of senescenceassociated heterochromatin foci were also shown. |
| Target gene: | STAT6//P38MAPK |
| Official symbol(s): | STAT6//P38MAPK |
| R-AG-Target gene: | Activation//Activation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | STAT6 phosphorylation was predominant by 10 min after IL-4 treatment.p38 MAPK as well as its upstream kinases, MEK3/6, were phosphorylated following IL-4 treatment. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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