| Gene name: | SIAH1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MRC-5 |
| Experiment: | Knockdown |
| Description: | The Siah1 knockdown cells had increased proliferation rate in the early phase of the experiment and had an extended replicative lifespan, which was approximately 2 or 3 PDL longer than control cells. |
| Target gene: | P53//TRF2 |
| Official symbol(s): | P53//TERF2 |
| R-AG-Target gene: | Upregulation//Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//qRT-PCR |
| Target gene description: | In these experiments, the expression of Siah1 protein was inversely correlated with the expression of TRF2 protein; Siah1 was decreased when TRF2 was increased,and Siah1 was increased when TRF2 was decreased.The overexpression of a stabilized form of Siah-1 resulted in the downregulation of TRF2.Decreased SIAH1 mRNA levels were also confirmed in cells with p53 knockdown.The overexpression of wild-type p53 led to increased Siah-1 and decreased TRF2. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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