| Gene name: | SIRT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HUC-F2 |
| Experiment: | SA-β-gal activity assay |
| Description: | Results clearly showed that SIRT1 significantly promoted proliferation and prevented replicative senescence HUC-F2 cells. |
| Target gene: | C-MYC//HTERT |
| Official symbol(s): | C-MYC//HTERT |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR//CHIP//Luciferase reporter assay |
| Target gene description: | The results indicated that SIRT1, as well as starvation conditions, increased the promoter activity of c-MYC [11] and the transcription of c-MYC gene. Further, we observed the increased amount of c-MYC recruited to the hTERT promoter. The results showed that SIRT1 significantly increased the transcriptional activation ability of c-MYC.Results showed that SIRT1, but not SIRT1-HY, increased hTERT transcription, as evidenced by the promoter assay and quantitativeRT-PCR (qRT-PCR). |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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