| Gene name: | SIRT6 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U2OS |
| Experiment: | SA-β-gal activity assay |
| Description: | We detected significantly increased numbers of senescent U2OS cells (over ~20-fold higher than control cells) within a week of SIRT6 depletion by lentiviral shRNAs, and increased senescence was observed as early as 72 hours after transient transfection of SIRT6 siRNAs. |
| Target gene: | H3K18AC |
| Official symbol(s): | H3K18AC |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Upon extending this analysis to new peptides, we found that SIRT6 robustly deacetylated lysine K18 on histone H3 peptides (H3K18Ac).SIRT6 also promoted H3K18Ac deacetylation when over-expressed in cells, while the mutant SIRT6 H133Y protein did not. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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