| Gene name: | CDKN2A |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HDF |
| Experiment: | Cell morphological analysis//qRT-PCR//Knockdown |
| Description: | This study showed that senescent HDFs transfected with p16INK4asiRNA showed changes of morphology from senescent morphology to morphology of young cells with the presence of small and spindle-shaped fibroblasts.The data showed that, in senescent HDFs, p16INK4amRNA was significantly upregulated (p < 0.05) compared to young HDF cells. |
| Target gene: | CYCLIN D1 |
| Official symbol(s): | CYCLIN D1 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Cells transfected with p16INK4a siRNA showed downregulation (p < 0.05) of cyclin D1 compared to untreated senescent cells.In senescent cells, cyclin D1 was upregulated significantly (p < 0.05) when compared to young cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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