| Gene name: | BLM |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | WI-38 |
| Gene ID: | 641 |
| Category: | protein coding |
| Phenotype: | Werner syndrome |
| Experimental category: | HL |
| PMID: | 16287861 |
| Experiment: | Cell morphological analysis//SA-β-gal activity assay//Knockdown |
| Description: | RNAi directed against BLM resulted in a similar or somewhat greater reduction in cell number and appearance of SA-β-Gal activity, albeit with less evident flattening morphology of the cells. |
| Target gene: | P16 |
| Official symbol(s): | P16 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Knockdown//Western blot |
| Target gene description: | Untransformed fibroblasts responded to acute knockdown of BLM with a minimal elevation of the levels of the p16 cell-cycle inhibitors within the time frame of 5 days. |
| Regulatory pathway: | P53//RB |
| R-AG-Pathway: | --//-- |
| Official symbol(s): | TP53//retinoblastoma |
| Pathway experiment: | Knockdown//Western blot |
| Pathway description: | Untransformed fibroblasts responded to acute knockdown of BLM with a minimal elevation of the levels of p21,the downstream p53 target within the time frame of 5 days .Acutely BLM-depleted cells also showed marked dephosphorylation of Rb protein. |
Annotation:
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