| Gene name: | TXNRD1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | NIH-3T3 |
| Experiment: | Western blot//SA-β-gal activity assay |
| Description: | We show that expression of F-A-TrxR1-HA inhibited SIPS in fibroblasts, as shown by the lesser number of senescence-associated β-galactosidase-positive cells after oxidative stress as compared with wt-TrxR1-HA-expressing cells.We found that expression of the constitutively Activate F-A-TrxR1-HA inhibited ROS-induced upregulation of p53, expression of p21Waf1/Cip1protein and activation of a p53 responsive element 24 h after oxidative stress,as compared with wt-TrxR1-HA. |
| Target gene: | CAVEOLIN-1 |
| Official symbol(s): | CAVEOLIN-1 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | We found that caveolin 1 inhibits TrxR1 activity by preventing the formation of TrxR1 homodimers, as shown by increased levels of dimeric TrxR1 in cells in which endogenous caveolin 1 expression was reduced by short interfering RNA. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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