| Gene name: | RB1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HCA2 |
| Experiment: | Western blot//SA-β-gal activity assay//FACS analysis |
| Description: | Transient expression (24 hr) of pRb7LP by the addition of doxycycline to G2 cells, in the presence of a Cdk2 inhibitor to prematurely activate Cdh1, resulted in impaired cell proliferation and an increase in the population of cells staining positive for SA-β gal.The resulting senescence phenotype of the cells was further confirmed by the induction of p16 and senescence-associated cytokines such as IL-6 and IL-8. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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