| Gene name: | BMP4 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | A549 |
| Gene ID: | 652 |
| Category: | protein coding |
| Phenotype: | Lung cancer |
| Experimental category: | L |
| PMID: | 12959928 |
| Experiment: | Cell morphological analysis//SA-β-gal activity assay |
| Description: | A change in morphology was apparent after 2 wk of treatment. The slower-growing cells were larger, flattened, and more granular than untreated cell;A fourfold increase in S-A-β-gal activity was seen after 17 days of BMP4 treatment;Laddering was reduced in untreated A549 cells grown for 17 days in low-serum conditions making them essentially quiescent and dramatically reduced in cells treated with BMP4 for 17 days and expressing the senescence biomarker SA-β-gal. |
| Target gene: | PERK//VEGF//BCL2 |
| Official symbol(s): | EIF2AK3//VEGFA//BCL2 |
| R-AG-Target gene: | Downregulation//Downregulation//Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | A decrease in proliferative and angiogenic phenotypic markers compared with untreated cells cultured under parallel low serum conditions, as shown by decreased p-ERK and VEGF expression, respectively.The expression of survival factor Bcl2 is lower in BMP4-treated cells, suggesting an increased potential for apoptosis in the senescent population. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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