| Gene name: | VDR |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | Femoral head |
| Cell name: | MSC |
| Experiment: | SA-β-gal activity assay//Cell proliferation assay |
| Description: | 1,25D3 treatment of hMSC leads to a significant inhibition of cell proliferation after 48 h (17% reduction;p,0.01) and 72 h (27% reduction; p,0.001);In stimulated hMSC(gray bar) a significant reduction of β-galactosidase staining was observed compared to unstimulated cells (black bar) (p,0.001). |
| Target gene: | P16 |
| Official symbol(s): | P16 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | qPCR |
| Target gene description: | The gene expression of the senescence-associated genes cyclin dependent kinase inhibitor 2B (P15), cyclin-dependent kinase inhibitor 2A (P16), cyclin-dependent kinase inhibitor 1A (P21) and proteasome 26S subunit, non-ATPase, 9 (P27) in hMSC cultured with or without 1,25D3 for four passages led to a significant 0.4-fold(p,0.05) downregulation of P16 gene expression. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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