| Gene name: | GATA4 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | Umbilical cord blood |
| Cell name: | MSC |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | The suppression of GATA4 in the progerin-expressing hMSCs significantly decreased SA-β-gal activity;The decrease in GATA4 also inhibited the induction of senescence mediated by CM from progerin expressing cells. |
| Target gene: | MCP-1//NF-?B |
| Official symbol(s): | CCL2//NFKB1 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR//Western blot |
| Target gene description: | GATA4 downregulation suppressed MCP-1 gene expression in progerin expressing hMSCs, suggesting that GATA4 regulates the SASP of hMSCs through MCP-1;The activation of NF-?B was also increased in response to progerin expression，however,the depletion of GATA4 decreased this activity. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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