| Gene name: | ERBB2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MCF 10A |
| Experiment: | Growth curve assay//Cell morphological analysis//SA-β-gal activity assay |
| Description: | When we expressed HER2 in HSF1-depleted cells, a significant growth inhibition was observed, associated with a significant change in cells’ appearance, including enlarged, flattened morphology and extensive vacuolization reminiscent of senescence.Expression of HER2 in shHSF1 MCF10A cells resulted in about 70% of β-gal-positive cells. |
| Target gene: | P21 |
| Official symbol(s): | P21 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | There was a marked induction of p21 upon expression of HER2 in shHSF1 cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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