| Gene name: | PRKCI |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MCF-7,T47D |
| Gene ID: | 5584 |
| Category: | protein coding |
| Phenotype: | Breast cancer |
| Experimental category: | HL |
| PMID: | 22120720 |
| Experiment: | SA-β-gal activity assay//Cell morphological analysis |
| Description: | PKCi depletion significantly increased the percentage of SA-β-gal-positive cells in both MCF7 and T47D cells. Cells that were SA-β-gal-positive showed an enlarged, flattened morphology. |
| Target gene: | P21 |
| Official symbol(s): | P21 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Immunostaining//SA-β-gal activity assay |
| Target gene description: | As with MCF7 breast cancer cells, senescence occurred in the absence of a detectable DNA-damage response and was dependent on the presence of p21. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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