| Gene name: | ING1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | Hs68 |
| Experiment: | SA-β-gal activity assay//BrdU assay |
| Description: | Cells treated with the agents noted above were tested periodically for SA-β-gal staining and BrdU incorporation,ING1a induced senescence by 36 hours and became maximal by 48 hours. |
| Regulatory pathway: | P16-RB |
| R-AG-Pathway: | Activation |
| Pathway experiment: | Western blot |
| Pathway description: | Consistent with ING1a inducing changes similar to those seen in replicative senescence, Rb and p16INK4a levels increased to similar degrees in response to ING1a expression and replicative senescence. |
Annotation:
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