| Gene name: | PFDN5 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MCF 10A,H1299 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | SA-β-Gal staining demonstrates that MM1 overexpression significantly increases the percentage of SA-β-Gal-positive cells, which is a hallmark of cell senescence, the protein level of cellular senescence marker PAI-1 is elevated. |
| Target gene: | C-MYC//CD4//ΔNP63α//HERC3 |
| Official symbol(s): | C-MYC//CD4//ΔNP63α//HERC3 |
| R-AG-Target gene: | Downregulation//Downregulation//--//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Knockdown//qRT-PCR |
| Target gene description: | The IB analysis demonstrates that c-Myc and its downstream target CDK4 are dramatically down-regulated by MM1.The results showed that up-regulation of MM1 induced by depletion of HERC3 also occurs in MCF-10A cells. Further study revealed that knockdown of HERC3 abrogates ΔNp63α-mediated down-regulation of MM1 protein levels. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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