| Gene name: | HBP1 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | 2BS |
| Experiment: | BrdU assay//SA-β-gal activity assay//Growth curve assay |
| Description: | HBP1 played a role in growth suppression, as shown by BrdU incorporation assay and growth curve.HBP1 also induced premature senescence, as demonstrated by an increase of SA-β-gal staining. |
| Target gene: | DNMT1 |
| Official symbol(s): | DNMT1 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Methylation |
| Target gene experiment: | Western blot//RT-PCR//Knockdown |
| Target gene description: | Exogenous HBP1 expression reduced DNMT1 protein (left) and mRNA (right) levels in both 2BS and WI-38 human fibroblasts.we used short hairpin RNA (shRNA) to knock down the HBP1 gene. An HBP1 knockdown increased DNMT1 protein and mRNA levels. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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