| Gene name: | NR2E1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Experiment: | Colony formation assay//BrdU assay//SA-β-gal activity assay//SAHF |
| Description: | NR2E1 expression resulted in an appreciable extension of replicative lifespan, as judged by cumulative population doublings and colony formation assays .A higher percentage of the NR2E1-expressing cells incorporated BrdU and a smaller percentage stained positively for SA-βGal activity, or showed evidence of senescence-associated heterochromatin foci；The expression of NR2E1 partially prevented the growth arrest and senescence observed upon RAS induction. |
| Target gene: | CBX7 |
| Official symbol(s): | CBX7 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Binding to promoter |
| Target gene experiment: | qRT–PCR |
| Target gene description: | We observed a direct correlation, suggesting that enhanced levels of NR2E1 associated with glioblastoma multiformeformation result in a concomitant increase in CBX7 expression . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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