| Gene name: | PLK1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MDA-MB-468 |
| Gene ID: | 5347 |
| Category: | protein coding |
| Phenotype: | Breast cancer |
| Experimental category: | L |
| PMID: | 25505268 |
| Experiment: | SA-β-gal activity assay//Western blot//EdU assay//DAPI staining |
| Description: | PLK1 inhibition also resulted in senescence induction and p16 up-regulation in addition to p21 up-regulation in MDA-MB-468 cells. |
| Target gene: | MIR-200C//MIR-141//BMI1//PRC1 |
| Official symbol(s): | MIR-200C//MIR-141//BMI1//PRC1 |
| R-AG-Target gene: | Downregulation//Downregulation//Upregulation//-- |
| Subcategory: | Unclear |
| Target gene experiment: | qRT-PCR//Western blot//Knockdown |
| Target gene description: | Our data indicated that indeed PLK1 knockdown results in up-regulation of miR-200c and miR-141, while PLK1 overexpression resulted in down-regulation of miR200c and miR-141 ；Our results indicated that indeed PLK1 overexpression leads to up-regulation of BMI1 and PRC1 activity. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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