AgingReG
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Aging Overview

Aging gene

Gene name: WT1
Aging type: Prevent
Aging characteristic:
Tissue type: --
Cell name: NCI-H522,NCI-H1437,NCI-H1568,NCI-H1650,NCI-H1975,NCI-H2126,NCI-H23,NCI-H358,NCI-H441,NCI-H460,NCI-H727,NCI-H1299,NCI-H2009,NCI-A549
Gene ID: 7490
Category: protein coding
Phenotype: Aging
Experimental category: HL
PMID: 20972333
Experiment: MTT assay//SA-β-gal activity assay
Description: A significant decrease in the cell viability of cell lines harboring KRAS mutations was observed in response to WT1 loss.Mutant KRAS NSCLC cell lines adopted a senescence-like appearance in response to WT1 knockdown, and this was confirmed by staining with SA-βgal.

Regulatory relationship

Regulatory pathway: KRAS
R-AG-Pathway: --
Official symbol(s): KRAS
Pathway experiment: SA-β-gal activity assay//Tumor formation assay
Pathway description: KrasG12D/+;Wt1Δ/Δ MEFs demonstrated a flattened morphology and stained positive for senescence-associated β-gal (SA-βgal). Wt1 suppression significantly decreased the size of tumors when compared with controls and to a level similar to that caused by suppression of Kras.

Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.


Pathway view

Activation of RAS in B cellsC-MYB transcription factor networkCD209 (DC-SIGN) signalingClass I PI3K signaling eventsConstitutive Signaling by EGFRvIIIConstitutive Signaling by Ligand-Responsive EGFR Cancer VariantsCXCR3-mediated signaling eventsDAP12 signalingDownstream signal transductionDownstream signaling in naïve CD8+ T cellsEGF signaling pathway ( EGF signaling pathway Diagram ) EGFR Transactivation by GastrinEGFR1EPHB forward signalingErbB1 downstream signalingErbB2/ErbB3 signaling eventsFc Epsilon Receptor I Signaling in Mast CellsFCERI mediated MAPK activationFGF signaling pathway ( FGF signaling pathway ) FGF8 signaling pathway(Mouse) ( FGF8 signaling (Mouse) ) FGF8 signaling pathway(Xenopus) ( FGF8 signaling (Xenopus) ) FRS-mediated FGFR1 signalingFRS-mediated FGFR2 signalingFRS-mediated FGFR3 signalingFRS-mediated FGFR4 signalingGMCSF-mediated signaling eventsGRB2 events in EGFR signalingGRB2 events in ERBB2 signalingHGF signaling pathway ( HGF signaling pathway ) IGF1 signaling pathway ( IGF1 signaling pathway ) IL2-mediated signaling eventsInflammation mediated by chemokine and cytokine signaling pathwayInsulin receptor signaling ( Insulin receptor signaling (D. melanogaster) ) Insulin receptor signaling (Mammal) ( Insulin receptor signaling (Mammal) ) Insulin receptor signalling cascadeIntegrin signaling pathway ( Integrin signaling pathway ) Internalization of ErbB1MAP2K and MAPK activationmTOR signaling pathwayNCAM signaling for neurite out-growthNegative regulation of MAPK pathwayNeurotrophic factor-mediated Trk receptor signalingNGF signaling pathway ( NGF signaling pathway ) p38MAPK eventsp53 pathway feedback loops 2PDGF signaling pathway ( PDGF signaling pathway ) PDGF signaling pathway (Mammal) ( PDGF signaling pathway ) PDGFR-beta signaling pathwayPlasma membrane estrogen receptor signalingPTK6 Regulates RHO GTPases, RAS GTPase and MAP kinasesRAF activationRaf activation signaling (through Grb2 and Sos) ( B cell receptor signaling ) Raf activation signaling (through Grb2 and Sos) ( CD4 T cell receptor signaling (ERK cascade) ) Raf activation signaling (through Grb2 and Sos) ( CD4 T cell receptor signaling ) Raf activation signaling (through Grb2 and Sos) ( JAK-STAT pathway and regulation pathway Diagram ) Raf activation signaling (through RasGRP) ( CD4 T cell receptor signaling (ERK cascade) ) Raf activation signaling (through RasGRP) ( CD4 T cell receptor signaling ) RAF/MAP kinase cascadeRas PathwayRas signaling in the CD4+ TCR pathwayRegulation of RAS by GAPsRegulation of Ras family activationSHC-mediated cascade:FGFR1SHC-mediated cascade:FGFR2SHC-mediated cascade:FGFR3SHC-mediated cascade:FGFR4SHC-related events triggered by IGF1RSHC1 events in EGFR signalingSHC1 events in ERBB2 signalingSHC1 events in ERBB4 signalingSHP2 signalingSignaling by FGFR1 in diseaseSignaling by FGFR2 in diseaseSignaling by FGFR3 fusions in cancerSignaling by FGFR3 point mutants in cancerSignaling by FGFR4 in diseaseSignaling by SCF-KITSignalling to RASSOS-mediated signallingTCR signaling in naïve CD4+ T cellsTCR signaling in naïve CD8+ T cellsTie2 SignalingTrk receptor signaling mediated by PI3K and PLC-gammaTrk receptor signaling mediated by the MAPK pathwayVEGFR2 mediated cell proliferationMAPK signaling pathwayMAPK signaling pathway - flyChemokine signaling pathwayDorso-ventral axis formationAxon guidanceVEGF signaling pathwayTight junctionGap junctionNatural killer cell mediated cytotoxicityT cell receptor signaling pathwayB cell receptor signaling pathwayFc epsilon RI signaling pathwayLong-term potentiationNeurotrophin signaling pathwayLong-term depressionRegulation of actin cytoskeletonInsulin signaling pathwayGnRH signaling pathwayProgesterone-mediated oocyte maturationMelanogenesisAldosterone-regulated sodium reabsorptionHepatitis CPathways in cancerColorectal cancerPancreatic cancerEndometrial cancerGliomaProstate cancerThyroid cancerAcute myeloid leukemiaNon-small cell lung cancerHs_Integrated_Breast_Cancer_Pathway_WP1984_82941Hs_VEGFA-VEGFR2_Signaling_Pathway_WP3888_90000Hs_IL-5_Signaling_Pathway_WP127_78498Hs_EGF-EGFR_Signaling_Pathway_WP437_79266Hs_Nanoparticle-mediated_activation_of_receptor_signaling_WP2643_87898
About risk SNP and eQTL

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Data source of:
Expression of gene(s)
Cell line (ENCODE) Primary cell (ENCODE) Normal tissue (GTEx) Cell line (CCLE)