| Gene name: | TP53 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90 |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | In TP53-deficient primary and tumour cell lines senescence decreased markedly and malic enzyme depletion lost its ability to induce this phenotype.By contrast, malic enzyme depletion did not cause cell death; it induced the expression of p53 target genes implicated in senescence but not apoptosis. |
| Target gene: | ME1//ME2 |
| Official symbol(s): | ME1//ME2 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | We knocked down TP53 in human osteosarcoma U2OS cells and normal diploid fibroblast IMR90 cells using short hairpin RNA (shRNA)，This led to a significant increase in messenger RNA levels of ME1 and ME2, accompanied by increased protein levels and total enzymatic activity of ME1 and ME2 . |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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