| Gene name: | PML |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MRC-5,WI-38 |
| Experiment: | Knockdown//SA-β-gal activity assay |
| Description: | PML knockdown caused a dose-dependent decrease in cell proliferation, morphological changes consistent with a senescent phenotype and an increased expression of the senescence-related β-galactosidase enzyme. |
| Target gene: | PML/RARα//P53//P16//P21 |
| Official symbol(s): | PML//P53//P16//P21 |
| R-AG-Target gene: | --//--//--//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | However, in PML/RARα expressing HPCs colocalization was only found in 15% of the cells. Moreover, 50% of the control cells had >10% of the PML signals colocalizing with telomeres whereas this was observed in only 3% of the PML/RARα cells.An increased expression of the p53, p16INK4a?and p21WAF1?proteins in PML-depleted cells with respect to control cells. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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