| Gene name: | USP1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | WI-38,BJ |
| Experiment: | qRT-PCR//Western blot//SA-β-gal activity assay |
| Description: | We confirmed that oncogenic RAS senescent cells have reduced USP1 transcript and protein levels compared to pre-senescent cells .Using of shUSP1-1, shUSP1-2, and shUSP1-3 induced a cell-cycle arrest with senescence features, including a perma-nent proliferative arrest,a flat cell morphology, and increased senescence-associated beta-galactosidase (SABG)positivity with a concomitant decrease in Ki67 expression. |
| Target gene: | KDM4A |
| Official symbol(s): | KDM4A |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | -- |
| Target gene description: | -- |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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