| Gene name: | TERF2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U2OS |
| Experiment: | SA-β-gal activity assay//PI staining |
| Description: | We analyzed cell cycle profiles in TRF2-depleted cells and found an increase in the proportion of cells in the G2 phase of cell cycle . following addition of DOX ,the number of TRF2-depleted cells compared with control uninduced cells progressively decreases,inducible clones became strongly positive for acidic βgal (SA-βgal), a marker of cellular senescence. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | TRF2-depleted cells (G10) p53 is phosphorylated and its levels increased. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
Loading,please wait...