| Gene name: | MEOX2 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | IMR-90,WI-38,HEKn |
| Experiment: | FACS analysis//SA-β-gal activity assay |
| Description: | MEOX2 -expressing cells exhibited reduced proliferative capability and progressive cell size increase,；Fibroblasts with forced MEOX2 expression also harbored significantly higher senescence-associated Beta-galactosidase activity，MEOX2 expression also led to an accumulation of cells in the G1 phase of the cell cycle, and a concomitant decrease of cells in S phase, consistent with cells undergoing senescence. |
| Target gene: | INK4A |
| Official symbol(s): | INK4A |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Binding to promoter |
| Target gene experiment: | Western blot//IP |
| Target gene description: | NK4a protein levels were increased two-fold by MEOX2 overexpression in fibroblasts .Immunoprecipitation of MEOX2-HA strongly enriched for sequences located within the INK4a promoter region. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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