| Gene name: | MUC4 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | UMSCC10B,UMSCC1 |
| Gene ID: | 4585 |
| Category: | protein coding |
| Phenotype: | Squamous cell carcinoma |
| Experimental category: | L |
| PMID: | 24747969 |
| Experiment: | Cell cycle analysis//Growth kinetics analysis//SA-β-gal activity assay |
| Description: | A significant decrease in growth rates of MUC4 KD SCC1 and SCC10B cells was observed indicating the role of MUC4 in cell proliferation.;Our SA-β-gal staining showed 37±4% and 27±6% positive in MUC4 KD SCC1 and SCC10B cells compared to 3±2% and 4±1% in control cells respectively. |
| Regulatory pathway: | P16-RB |
| R-AG-Pathway: | -- |
| Pathway experiment: | Western blot//SA-β-gal activity assay |
| Pathway description: | We observed significant upregulation of p16 protein and downregulation of cyclin E, cyclin D1, decreased phosphorylation of pRb in MUC4 KD cells compared to control cells. |
Annotation:
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