| Gene name: | GLO1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | RPTEC |
| Experiment: | SA-β-gal activity assay//Western blot |
| Description: | Empty vector-transfected cells treated with etoposide showed a significant increase in SABG-positive cells, by 2.3 ± 1.0-fold, which was significantly suppressed by GLO1 overexpression.When GLO1-knocked down cells were treated with etoposide, the number of cells positive for SABG staining was significantly increased, compared with control siRNA-transfected cells . Other senescence markers, such as transcript expression level of p53, p21WAF1/CIP1, and p16INK4A or protein expression level of p53 in whole cellular lysate, were also markedly augmented by knockdown of GLO1. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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