| Gene name: | FOXO3 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MEF |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | We delivered the siRNA into MEFs and confirmed that transfection with this siRNA silenced circ-Foxo3 levels. We also delivered an siRNA targeting the linear mRNA of Foxo3 into the cells. The cells transfected with circ-Foxo3 siRNA showed less β-gal staining than the cells transfected with Foxo3 siRNA or the control oligo. Primary cardiomyocytes transfected with the siRNA also displayed lower levels of beta-Gal staining and circ-Foxo3 expression. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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