| Gene name: | H1-3 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | WI-38 |
| Experiment: | BrdU assay//SA-β-gal activity assay//Cell morphological analysis |
| Description: | Concomitant with the decreases in histone H1 protein levels, the expression of N fusions caused severe growth defects in young WI-38 cells as revealed by the growth curves and the BrdU incorporation assay. N fusions also induced a large, flat morphology and increased the percentage of SA–β-gal–positive cells, suggesting that the ectopic expression of N fusions induced premature senescence in WI-38 cells. |
| Target gene: | P53//P21//RB |
| Official symbol(s): | P53//P21//RB |
| R-AG-Target gene: | --//Upregulation//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//Cell transfection |
| Target gene description: | Cells expressing N fusions showed decreased levels of phosphorylated Rb and cyclin A and increased levels of p21 and phosphorylated p53. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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