| Gene name: | ATF3 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HKC,SCC |
| Gene ID: | 467 |
| Category: | protein coding |
| Phenotype: | Skin cancer |
| Experimental category: | HL |
| PMID: | 20485437 |
| Experiment: | SA-β-gal activity assay |
| Description: | In vivo, ectopic ATF3 promoted tumorigenicity of H-rasV12-expressing HKCs and SCC cells, producing aggressive tumours with reduced senescence as those caused by calcineurin/NFAT inhibitors. Conversely, Atf3 knockdown overcame the tumour-promoting effects of these compounds and restored senescence. |
| Target gene: | P53 |
| Official symbol(s): | P53 |
| R-AG-Target gene: | Downregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot//qRT-PCR |
| Target gene description: | Functionally, ectopic ATF3 expression, at levels comparable to those occurring in SCCs from CsA-treated patients ,blocked expression of p53 and senescence-associated genes. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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