| Gene name: | PRKD2 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | U87,GM133 |
| Gene ID: | 25865 |
| Category: | protein coding |
| Phenotype: | Glioblastoma |
| Experimental category: | L |
| PMID: | 24463355 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | Silencing of PRKD2 induced acidic senescence-associated β-galactosidase activity (SA-β-gal) in U87MG (64+10.4% positive) and GM133 (41+ 5.4% positive) cells. SA-β-gal activity was also observed in both primary glioma cultures (GBM2, Gli25) in response to PRKD2 silencing. |
| Regulatory pathway: | P53 |
| R-AG-Pathway: | -- |
| Official symbol(s): | TP53 |
| Pathway experiment: | qPCR//Immunoblotting |
| Pathway description: | Moreover, PRKD2-deficient cells showed a distinct reduction in the expression of c-Myc on mRNA and protein level. None of these alterations were observed in p53mut GM133 cells . mRNA expression of transcription factor E2F1 was significantly attenuated in p53wt U87MG and p53mut GM133 cells. |
Annotation:
Loading,please wait...