| Gene name: | HRH4 |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | MDA-MB-231,MCF-7 |
| Gene ID: | 59340 |
| Category: | protein coding |
| Phenotype: | Breast cancer |
| Experimental category: | L |
| PMID: | 21622113 |
| Experiment: | SA-β-gal activity assay |
| Description: | Present results indicate that the negative effect on proliferation exerted by histamine in MDA-MB-231 cells was elated to a 2-fold increase in cell senescence. In addition, this effect was reversed by JNJ7777120 treatment and H4R agonists mimicked histamine effect, suggesting the involvement of H4R in histamine-induced cell senescence .In the same way, histamine was able to augment the percentage of MCF-7 senescent cells (15.7±1.3 vs. 7.8±0.4 in untreated, P<0.001), which was partially blocked by the treatment with JNJ7777120. Moreover, H4R agonists elicited a similar response, increasing cell senescence. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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