| Gene name: | ARID1A |
| Aging type: | Accelerate |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HPNE |
| Gene ID: | 8289 |
| Category: | protein coding |
| Phenotype: | Pancreatic cancer |
| Experimental category: | L |
| PMID: | 28942143 |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | ARID1A knockdown had no effect on cell apoptosis as demonstrated by Annexin V/Propidium Iodide apoptosis assay, but accelerated cell cycle progression in HPNE/KRASG12D cells. Second, ARID1A knockdown significantly reduced the percentage of senescence-associated bgal staining-positive cells. Third, accelerated cell cycle progression and inhibited senescence were also observed in the stable HPNE/KRASG12D/shARID1A cells compared with HPNE/KRASG12D/shNC control cells. |
| Target gene: | P16 |
| Official symbol(s): | P16 |
| R-AG-Target gene: | Upregulation |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | The results showed that restored ARID1A expression led to increased expression of p16, promotion of cell senescence. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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