| Gene name: | SIRT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | CEP |
| Gene ID: | 23411 |
| Category: | protein coding |
| Phenotype: | Disc degenerative disease |
| Experimental category: | L |
| PMID: | 26940203 |
| Experiment: | SA-β-gal activity assay |
| Description: | The overexpression of SIRT1 also decreased the population of G1 phase cells (p< 0.05), the percentege of SA-β-Gal-positive cells (blue), and staining intensity of the CEP cells. |
| Regulatory pathway: | P53-P21 |
| R-AG-Pathway: | Downregulation |
| Official symbol(s): | TP53-CDKN1A |
| Pathway experiment: | Western blot |
| Pathway description: | The overexpression of SIRT1 and inhibition of endogenous SIRT1 activity significantly influenced the p53/p21 pathway and, thereby, CEP cell senescence. |
Annotation:
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