AgingReG
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Aging Overview

Aging gene

Gene name: CABLES1
Aging type: Accelerate
Aging characteristic:
Tissue type: --
Cell name: HUVEC
Gene ID: 91768
Category: protein coding
Phenotype: Aging
Experimental category: L
PMID: 28118639
Experiment: BrdU assay//Flow cytometry//SA-β-gal activity assay
Description: The EdU results showed that the Cables1 transfection reduced cell proliferation. Similar results were also observed by flow cytometry. The results suggested that HUVECs had a lower rate of proliferation (S: 3.00 ± 0.20%) in the Cables1 group than in the control group (S: 10.78 ± 0.9%). Cellular senescence was evaluated after Ang II treatment, and SA-Gal activity was found to be significantly increased in Cables1-transfected HUVECs compared with the control cells.

Regulatory relationship

Regulatory pathway: P21
R-AG-Pathway: Upregulation
Official symbol(s): CDKN1A
Pathway experiment: Western blot
Pathway description: p21 activation was analyzed by Western blotting. The results showed that Cables1 significantly increased p21 expression compared with the control group.

Aging network

Annotation:

The green line represents Upregulation.

The purple line represents Downregulation.

The orange line represents Activation.

The yellow line represents Inhibition.

The gray line represents Unclear.


Pathway view

AKT phosphorylates targets in the cytosolAngiopoietin receptor Tie2-mediated signalingC-MYB transcription factor networkCi/Gli processing signaling ( Hedgehog signaling pathway ) Class I PI3K signaling events mediated by AktConstitutive Signaling by AKT1 E17K in CancerCyclin A:Cdk2-associated events at S phase entryCyclin D associated events in G1Cyclin E associated events during G1/S transitionDirect p53 effectorsDNA Damage/Telomere Stress Induced SenescenceE2F transcription factor networkFormation of Senescence-Associated Heterochromatin Foci (SAHF)Gli processing signaling ( Hedgehog signaling pathway ) Glucocorticoid receptor regulatory networkInterleukin signaling pathwayNotch signaling pathwayOrc1 removal from chromatinp53-Dependent G1 DNA Damage Responsep53 pathwayp53 pathway feedback loops 2p73 transcription factor networkRegulation of nuclear SMAD2/3 signalingRegulation of retinoblastoma proteinSCF(Skp2)-mediated degradation of p27/p21Senescence-Associated Secretory Phenotype (SASP)Signaling events mediated by HDAC Class IIISignaling events mediated by PRLTGF_beta_ReceptorThe role of GTSE1 in G2/M progression after G2 checkpointTP53 Regulates Transcription of Genes Involved in G1 Cell Cycle ArrestValidated targets of C-MYC transcriptional repressionValidated transcriptional targets of TAp63 isoformsVinblastine Action PathwayVincristine Action PathwayVindesine Action PathwayVinorelbine Action PathwayErbB signaling pathwayCell cyclep53 signaling pathwayHepatitis CPathways in cancerGliomaProstate cancerMelanomaBladder cancerChronic myeloid leukemiaHs_Cell_Cycle_WP179_89516Hs_ErbB_Signaling_Pathway_WP673_91869Hs_DNA_Damage_Response_(only_ATM_dependent)_WP710_79974Hs_DNA_Damage_Response_WP707_82937Hs_miRNA_Regulation_of_DNA_Damage_Response_WP1530_84694Hs_Apoptosis-related_network_due_to_altered_Notch3_in_ovarian_cancer_WP2864_79278Hs_miRNAs_involved_in_DNA_damage_response_WP1545_84697Hs_Hepatitis_C_and_Hepatocellular_Carcinoma_WP3646_88640Hs_Senescence_and_Autophagy_in_Cancer_WP615_81193Hs_Integrated_Cancer_Pathway_WP1971_82939Hs_ATM_Signaling_Pathway_WP2516_90247Hs_LncRNA-mediated_mechanisms_of_therapeutic_resistance_WP3672_87395Hs_Signaling_Pathways_in_Glioblastoma_WP2261_89520Hs_AMP-activated_Protein_Kinase_(AMPK)_Signaling_WP1403_90259Hs_Aryl_Hydrocarbon_Receptor_WP2586_91687Hs_Retinoblastoma_(RB)_in_Cancer_WP2446_87639Hs_TGF-beta_Signaling_Pathway_WP366_90028Hs_Androgen_receptor_signaling_pathway_WP138_79958
About risk SNP and eQTL

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Data source of:
Expression of gene(s)
Cell line (ENCODE) Primary cell (ENCODE) Normal tissue (GTEx) Cell line (CCLE)