| Gene name: | PINK1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | NPC |
| Experiment: | SA-β-gal activity assay//Knockdown |
| Description: | These results indicated that PINK1/Parkin mediated mitophagy was inhibited in NPCs by down-regulation of PINK1. Furthermore, SA-β-Gal staining results showed that NPCs suffered PINK1-shRNA transfection accompanying with H2O2 treatment had the highest percentage of SA-β-Gal-positive cells (blue), and staining intensity.However, down-regulating PINK1 alone didn't increase the percentage of SA β-Gal-positive cells and staining intensity comparing with the control group. |
| Target gene: | PARKIN |
| Official symbol(s): | PARKIN |
| R-AG-Target gene: | -- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | The expression of LC-3 II/I decreased and Parkin, P62 increased markedly in NPCs with PINK1-shRNA transfection. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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