| Gene name: | SIRT1 |
| Aging type: | Prevent |
| Aging characteristic: |
| Tissue type: | -- |
| Cell name: | HDF |
| Experiment: | SA-β-gal activity assay//Flow cytometry |
| Description: | SIRT1 adenovirus resulted in the marked upregulation of SIRT1 protein. Furthermore, cells overexpressing SIRT1 showed attenuated UVB-induced cell senescence, In addition, SIRT1 overexpression significantly upregulated cell growth and rescued cells from G1 cell cycle arrest. |
| Target gene: | FOXO3α//P53 |
| Official symbol(s): | FOXO3//P53 |
| R-AG-Target gene: | --//-- |
| Subcategory: | Unclear |
| Target gene experiment: | Western blot |
| Target gene description: | Total acetylation of p53 and acetylation of p53 at Lys382 were increased.SIRT1 overexpression decreased the UVB-induced acetylation of p53. These results suggest that overexpressed SIRT1 deacetylates p53 and FOXO3α to elicit its protective action against the UVB-induced senescence. |
| Regulatory pathway: | -- |
| R-AG-Pathway: | -- |
| Pathway experiment: | -- |
| Pathway description: | -- |
Annotation:
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